Gene
alkbh8
- ID
- ZDB-GENE-100922-251
- Name
- alkB homolog 8, tRNA methyltransferase
- Symbol
- alkbh8 Nomenclature History
- Previous Names
-
- si:dkey-255n6.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to act upstream of or within methylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 71. Orthologous to human ALKBH8 (alkB homolog 8, tRNA methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 71 | Alliance | Intellectual developmental disorder, autosomal recessive 71 | 618504 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR013216 | Methyltransferase type 11 |
| Domain | IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Domain | IPR034256 | ALKBH8, RNA recognition motif |
| Family | IPR051422 | AlkB Family tRNA Methyltransferase/Dioxygenase |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Domain Details Per Protein
| Protein | Length | AlkB Family tRNA Methyltransferase/Dioxygenase | ALKBH8, RNA recognition motif | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Methyltransferase type 11 | Nucleotide-binding alpha-beta plait domain superfamily | Oxoglutarate/iron-dependent dioxygenase domain | RNA-binding domain superfamily | RNA recognition motif domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8I1
|
557 | ||||||||||
|
UniProtKB:E9QB52
|
666 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alkbh8-201
(1)
|
Ensembl | 2,164 nt |
Interactions and Pathways
No data available
Plasmids
No data available