Gene

fbxo21

ID

ZDB-GENE-100922-229

Name

F-box protein 21

Symbol

fbxo21 Nomenclature History

Previous Names

si:ch211-42a13.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Orthologous to human FBXO21 (F-box protein 21).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa10928	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33541	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With fbxo21 Human Ortholog

No data available

Associated With fbxo21 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Domain	IPR011722	Hemimethylated DNA-binding domain
Domain	IPR032698	Protein SirB1, N-terminal
Homologous_superfamily	IPR036047	F-box-like domain superfamily
Homologous_superfamily	IPR036623	Hemimethylated DNA-binding domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	F-box domain	F-box-like domain superfamily	Hemimethylated DNA-binding domain	Hemimethylated DNA-binding domain superfamily	Protein SirB1, N-terminal
UniProtKB:A0A8N7T7V0	InterPro	637

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 5

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fbxo21-201 (1) Ensembl	Ensembl		1,840 nt	Select Tool ZFIN BLAST
ncRNA	fbxo21-002 (1) Ensembl	Ensembl		516 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-42A13	CT583689	ZFIN Curated Data
Contained in	BAC	CH211-250A16	AL935185	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_691038 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935185 (1)	191281 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8N7T7V0 (1)	637 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	FBXO21	12	Ensembl:ENSG00000135108 Gene:23014 HGNC:13592 OMIM:609095	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Fbxo21	5	Ensembl:ENSMUSG00000032898 Gene:231670 MGI:1924223	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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