Gene
clstn3
- ID
- ZDB-GENE-100921-73
- Name
- calsyntenin 3
- Symbol
- clstn3 Nomenclature History
- Previous Names
-
- si:dkey-197a20.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables cell-cell adhesion mediator activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and synapse. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in forebrain; hindbrain; midbrain; spinal cord; and telencephalon. Orthologous to human CLSTN3 (calsyntenin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Ortiz-Medina et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32075 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin-like | Cadherin-like superfamily | Calsyntenin, C-terminal | Concanavalin A-like lectin/glucanase domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PFP2 | InterPro | 956 | ||||
| UniProtKB:A0A9V2TXN1 | InterPro | 956 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clstn3-201
(1)
|
Ensembl | 6,932 nt | ||
| mRNA |
clstn3-202
(1)
|
Ensembl | 840 nt | ||
| mRNA |
clstn3-203
(1)
|
Ensembl | 3,190 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-197A20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423876 (1) | 3785 nt | ||
| Genomic | GenBank:BX001019 (1) | 226271 nt | ||
| Polypeptide | UniProtKB:A0A8M9PFP2 (1) | 956 aa |
- Petit, J., Bailey, E.C., Wheeler, R.T., de Oliveira, C.A.F., Forlenza, M., Wiegertjes, G.F. (2019) Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway. Frontiers in immunology. 10:280
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ortiz-Medina, H., Emond, M.R., Jontes, J.D. (2015) Zebrafish Calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats. Neuroscience. 286:87-96
- Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2015) First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 10:e0126378
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