Gene

lipeb

ID

ZDB-GENE-100921-71

Name

lipase, hormone-sensitive b

Symbol

lipeb Nomenclature History

Previous Names

si:ch211-194b7.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable sterol esterase activity and triglyceride lipase activity. Predicted to be involved in triglyceride catabolic process. Predicted to act upstream of or within cholesterol metabolic process and lipid catabolic process. Predicted to be located in caveola and lipid droplet. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lipeb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial partial lipodystrophy type 6	Alliance	Lipodystrophy, familial partial, type 6	615980

Associated With lipeb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR002168	Lipase, GDXG, putative histidine active site
Active_site	IPR033140	Lipase, GDXG, putative serine active site
Domain	IPR010468	Hormone-sensitive lipase, N-terminal
Domain	IPR013094	Alpha/beta hydrolase fold-3
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold

Domain Details Per Protein

Protein	Length	Alpha/Beta hydrolase fold	Alpha/beta hydrolase fold-3	Hormone-sensitive lipase, N-terminal	Lipase, GDXG, putative histidine active site	Lipase, GDXG, putative serine active site
UniProtKB:A0A8M3AI41 InterPro	881
UniProtKB:A0A8M3ATG0 InterPro	894
UniProtKB:A0A8M3AJ48 InterPro	895
UniProtKB:A0A8M3B1P6 InterPro	857
UniProtKB:A0A8M3AQL5 InterPro	886
UniProtKB:A0A8M3AJ52 InterPro	851

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lipeb-201 (1) Ensembl	Ensembl		2,719 nt	Select Tool ZFIN BLAST
mRNA	lipeb-202 (1) Ensembl	Ensembl		2,547 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations