Gene

kcnn3

ID

ZDB-GENE-100921-56

Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Symbol

kcnn3 Nomenclature History

Previous Names

si:dkey-45h18.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in Z disc and membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in brain; heart; segmental plate; somite; and tail bud. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnn3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Zimmermann-Laband syndrome 3	618658

Associated With kcnn3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004178	Calmodulin-binding domain
Domain	IPR013099	Potassium channel domain
Family	IPR015449	Potassium channel, calcium-activated, SK
Homologous_superfamily	IPR036122	SK, calmodulin-binding domain superfamily