Gene

syngap1b

ID
ZDB-GENE-100921-2
Name
synaptic Ras GTPase activating protein 1b
Symbol
syngap1b Nomenclature History
Previous Names
  • syngap1
  • si:dkey-246f6.1
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity. Acts upstream of or within brain morphogenesis and swimming behavior. Is expressed in hindbrain and optic tectum. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 5. Orthologous to human SYNGAP1 (synaptic Ras GTPase activating protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With syngap1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 5 Alliance Intellectual developmental disorder, autosomal dominant 5 612621
Associated With syngap1b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023152 Ras GTPase-activating protein, conserved site
Domain IPR000008 C2 domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR001936 Ras GTPase-activating domain
Domain IPR021887 Disabled homolog 2-interacting protein, C-terminal domain
Family IPR039360 Ras GTPase-activating protein
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA syngap1b-201 (1) Ensembl 7,229 nt
mRNA syngap1b-202 (1) Ensembl 7,300 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations