Gene
myh14
- ID
- ZDB-GENE-100921-1
- Name
- myosin, heavy chain 14, non-muscle
- Symbol
- myh14 Nomenclature History
- Previous Names
-
- si:ch211-120k19.2
- si:ch211-120k19.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actomyosin structure organization; mitotic cytokinesis; and regulation of cell shape. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in heart; immature eye; nervous system; otic vesicle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Huang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 4A | Alliance | Deafness, autosomal dominant 4A | 600652 |
| ?Peripheral neuropathy, myopathy, hoarseness, and hearing loss | 614369 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AQG4
|
2065 | |||||||
|
UniProtKB:A0A8M3AJ07
|
2049 | |||||||
|
UniProtKB:A0A8M3B1K3
|
2056 | |||||||
|
UniProtKB:A0A8M3AHY4
|
2061 | |||||||
|
UniProtKB:A0A8M2B482
|
2060 | |||||||
|
UniProtKB:A0A8M2B4A6
|
2036 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance