Gene

pcsk6

ID

ZDB-GENE-100908-1

Name

proprotein convertase subtilisin/kexin type 6

Symbol

pcsk6 Nomenclature History

Previous Names

im:7140527

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within proteolysis. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7140527 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pcsk6 Human Ortholog

No data available

Associated With pcsk6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR023828	Peptidase S8, subtilisin, Ser-active site
Domain	IPR000209	Peptidase S8/S53 domain
Domain	IPR000742	EGF-like domain
Domain	IPR002884	P domain
Domain	IPR010909	PLAC
Domain	IPR032778	Growth factor receptor domain 4
Domain	IPR034182	Kexin/furin catalytic domain
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036852	Peptidase S8/S53 domain superfamily
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Additional Resources	Length	EGF-like domain	Furin-like repeat	Galactose-binding-like domain superfamily	Growth factor receptor cysteine-rich domain superfamily	Growth factor receptor domain 4	Kexin/furin catalytic domain	P domain	Peptidase S8/S53 domain	Peptidase S8/S53 domain superfamily	Peptidase S8, subtilisin, Ser-active site	PLAC
UniProtKB:A0A8M9QIA8	InterPro	869

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pcsk6-201 (1) Ensembl	Ensembl		1,590 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations