Gene
itgb6
- ID
- ZDB-GENE-100812-2
- Name
- integrin, beta 6
- Symbol
- itgb6 Nomenclature History
- Previous Names
-
- im:7165241
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in anchoring junction and plasma membrane. Predicted to be part of integrin alphav-beta6 complex. Predicted to be active in cell surface and focal adhesion. Is expressed in several structures, including adaxial cell; liver; musculature system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7165241 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6193 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amelogenesis imperfecta type 1H | Alliance | Amelogenesis imperfecta, type IH | 616221 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Integrin beta, epidermal growth factor-like domain 1 | Integrin beta N-terminal | Integrin beta subunit | Integrin beta subunit, cytoplasmic domain | Integrin beta subunit, tail | Integrin beta subunit, VWA domain | Integrin beta tail domain superfamily | Integrin domain superfamily | PSI domain | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QGX0 | InterPro | 782 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153G16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7165241 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003199426 (1) | 3009 nt | ||
| Genomic | GenBank:CR792451 (2) | 178736 nt | ||
| Polypeptide | UniProtKB:F1QGX0 (1) | 782 aa |
- Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Zagury, J.F., Sieger, D. (2022) Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Glia. 70(6):1027-1051
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Wang, J., Leng, X., Wang, G., Wan, X., Cao, H. (2017) The construction of intrahepatic cholangiocarcinoma model in zebrafish. Scientific Reports. 7:13419
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kasai, K., Nishiyama, N., and Yamauchi, K. (2013) Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses. Gene. 531(2):326-336
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