Gene

c4b

ID
ZDB-GENE-100805-2
Name
complement C4B (Chido/Rodgers blood group)
Symbol
c4b Nomenclature History
Previous Names
  • c4-2 (1)
  • c4bl
  • si:dkey-8k3.2
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
complement component 4b deficiency Alliance C4B deficiency 614379
Associated With c4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
Conserved_site IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain IPR000020 Anaphylatoxin/fibulin
Domain IPR001134 Netrin domain
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
Domain IPR011625 Alpha-2-macroglobulin, bait region domain
Domain IPR011626 Alpha-macroglobulin-like, TED domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR040839 Macroglobulin domain MG4
Domain IPR041555 Macroglobulin domain MG3
Family IPR050473 Alpha-2-macroglobulin/Complement system
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily IPR008964 Invasin/intimin cell-adhesion fragments
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR018081 Anaphylatoxin, complement system
Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-2-macroglobulin/Complement system Alpha-2-macroglobulin, conserved site Alpha-macroglobulin-like, TED domain Alpha-macroglobulin-like, thiol-ester bond-forming region Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Anaphylatoxin, complement system Anaphylatoxin/fibulin Immunoglobulin-like fold Invasin/intimin cell-adhesion fragments Macroglobulin domain Macroglobulin domain MG3 Macroglobulin domain MG4 Netrin domain Netrin module, non-TIMP type Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:A0A8M1Q1D0 1717
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations