Gene
c4b
- ID
- ZDB-GENE-100805-2
- Name
- complement C4B (Chido/Rodgers blood group)
- Symbol
- c4b Nomenclature History
- Previous Names
-
- c4-2 (1)
- c4bl
- si:dkey-8k3.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complement component 4b deficiency | Alliance | C4B deficiency | 614379 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019742 | Alpha-2-macroglobulin, conserved site |
| Conserved_site | IPR047565 | Alpha-macroglobulin-like, thiol-ester bond-forming region |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR040839 | Macroglobulin domain MG4 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008964 | Invasin/intimin cell-adhesion fragments |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-2-macroglobulin, conserved site | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Immunoglobulin-like fold | Invasin/intimin cell-adhesion fragments | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1Q1D0
|
1717 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| aberrant processed transcript |
si:dkey-8k3.2-201
(1)
|
Havana | 866 nt | |
| mRNA |
si:dkey-8k3.2-202
(1)
|
Havana | 5339 nt | |
| ncRNA |
ottdart00000052435
(1)
|
Havana | 760 nt |
Interactions and Pathways
No data available
Plasmids
No data available