kcnh2b

ID

ZDB-GENE-100629-2

Name

potassium voltage-gated channel, subfamily H (eag-related), member 2b

Symbol

kcnh2b Nomenclature History

Previous Names

kcnh2l
zerg-24 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including membrane repolarization during cardiac muscle cell action potential; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2).

Genome Resources

Alliance (1)
Gene:100463518 (1)

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Leong et al., 2010

Cross-Species Comparison

Alliance

High Throughput Data

Expression Atlas

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnh2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
long QT syndrome 2	Alliance	Long QT syndrome 2	613688
short QT syndrome	Alliance	Short QT syndrome 1	609620

Associated With kcnh2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M6YY94	InterPro	1177
UniProtKB:A0AC58ISU9	InterPro	1173
UniProtKB:A0AC58ISV6	InterPro	1177
UniProtKB:A0AC58ISW1	InterPro	829
UniProtKB:A0AC58ISX0	InterPro	837
UniProtKB:A0AC58ISX1	InterPro	841
UniProtKB:A0AC58ISX6	InterPro	833
UniProtKB:A0AC58ISX9	InterPro	1050
UniProtKB:A0AC58ISY3	InterPro	1127
UniProtKB:A0AC58ISY6	InterPro	1054
UniProtKB:A0AC58ISZ2	InterPro	1127