Gene
uqcc6
- ID
- ZDB-GENE-100427-3
- Name
- ubiquinol-cytochrome c reductase complex assembly factor 6
- Symbol
- uqcc6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in cardiac muscle and skeletal muscle. Orthologous to human UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhang et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zhang et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sdm1 | Allele with one deletion | Unknown | Exon Loss | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-uqcc6 | Zhang et al., 2020 | |
| CRISPR2-uqcc6 | Zhang et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR027858 | Protein BRAWNIN |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein BRAWNIN |
|---|---|---|---|
| UniProtKB:E7EXZ6 | InterPro | 65 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-68a17.7-201
(1)
|
Ensembl | 591 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-68A17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001135573 (1) | 587 nt | ||
| Genomic | GenBank:BX897714 (1) | 184435 nt | ||
| Polypeptide | UniProtKB:E7EXZ6 (1) | 65 aa |
- Zhang, S., Reljić, B., Liang, C., Kerouanton, B., Francisco, J.C., Peh, J.H., Mary, C., Jagannathan, N.S., Olexiouk, V., Tang, C., Fidelito, G., Nama, S., Cheng, R.K., Wee, C.L., Wang, L.C., Duek Roggli, P., Sampath, P., Lane, L., Petretto, E., Sobota, R.M., Jesuthasan, S., Tucker-Kellogg, L., Reversade, B., Menschaert, G., Sun, L., Stroud, D.A., Ho, L. (2020) Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Nature communications. 11:1312
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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