Gene
brsk2b
- ID
- ZDB-GENE-100422-3
- Name
- BR serine/threonine kinase 2b
- Symbol
- brsk2b Nomenclature History
- Previous Names
-
- zmp:0000000828
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within social behavior; swimming behavior; and thigmotaxis. Predicted to be active in centrosome. Is expressed in brain. Orthologous to human BRSK2 (BR serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Deng et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRSK1/2-like, UBA domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B1F0 | InterPro | 886 | |||||
| UniProtKB:A0A8M3AUI3 | InterPro | 881 | |||||
| UniProtKB:A0A8M3AUH0 | InterPro | 827 | |||||
| UniProtKB:A0A8M3BB82 | InterPro | 863 | |||||
| UniProtKB:A0A8M6Z088 | InterPro | 736 | |||||
| UniProtKB:A0A8M9PQ27 | InterPro | 822 | |||||
| UniProtKB:A0A8M1QHP3 | InterPro | 713 | |||||
| UniProtKB:A0AB32TW61 | InterPro | 804 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
brsk2b-201
(1)
|
Ensembl | 2,278 nt | ||
| mRNA |
brsk2b-202
(1)
|
Ensembl | 318 nt | ||
| mRNA |
brsk2b-203
(1)
|
Ensembl | 4,281 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009303425 (1) | 4789 nt | ||
| Genomic | GenBank:BX321910 (1) | 167869 nt | ||
| Polypeptide | UniProtKB:A0A8M3B1F0 (1) | 886 aa |
- Comparative Orthology
- Alliance
- Deng, J., Liu, C., Hu, M., Hu, C., Lin, J., Li, Q., Xu, X. (2023) Dynamic Regulation of brsk2 in the Social and Motor Development of Zebrafish: A Developmental Behavior Analysis. International Journal of Molecular Sciences. 24(22):
- Deng, J., Wang, Y., Hu, M., Lin, J., Li, Q., Liu, C., Xu, X. (2022) Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism. Frontiers in molecular neuroscience. 15:904935
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 5 of 5
Show