Gene
ttc17
- ID
- ZDB-GENE-100422-15
- Name
- tetratricopeptide repeat domain 17
- Symbol
- ttc17 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in actin filament polymerization and cilium organization. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in plasma membrane. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in female organism. Orthologous to human TTC17 (tetratricopeptide repeat domain 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ttc17 | Lam et al., 2021 | |
| MO1-ttc17 | N/A | Bontems et al., 2014 |
| MO2-ttc17 | N/A | Bontems et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Tetratricopeptide repeat 2 | Tetratricopeptide repeat protein 17 |
|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UTG0
|
1198 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423800 (1) | 3978 nt | ||
| Genomic | GenBank:CR376774 (1) | 92513 nt | ||
| Polypeptide | UniProtKB:A0A8N7UTG0 (1) | 1198 aa |
- Lam, W.Y., Tang, C.S., So, M.T., Yue, H., Hsu, J.S., Chung, P.H., Nicholls, J.M., Yeung, F., Lee, C.D., Ngo, D.N., Nguyen, P.A.H., Mitchison, H.M., Jenkins, D., O'Callaghan, C., Garcia-Barceló, M.M., Lee, S.L., Sham, P.C., Lui, V.C., Tam, P.K. (2021) Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism. EBioMedicine. 71:103530
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bontems, F., Fish, R.J., Borlat, I., Lembo, F., Chocu, S., Chalmel, F., Borg, J.P., Pineau, C., Neerman-Arbez, M., Bairoch, A., and Lane, L. (2014) C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. PLoS One. 9(1):e86476
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