Gene
tymp
- ID
- ZDB-GENE-100415-1
- Name
- thymidine phosphorylase
- Symbol
- tymp Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have 1,4-alpha-oligoglucan phosphorylase activity. Predicted to be involved in pyrimidine nucleobase metabolic process. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 1 | Alliance | Mitochondrial DNA depletion syndrome 1 (MNGIE type) | 603041 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017872 | Pyrimidine-nucleoside phosphorylase, conserved site |
| Domain | IPR000312 | Glycosyl transferase, family 3 |
| Domain | IPR013102 | Pyrimidine nucleoside phosphorylase, C-terminal |
| Domain | IPR017459 | Glycosyl transferase family 3, N-terminal domain |
| Family | IPR000053 | Thymidine/pyrimidine-nucleoside phosphorylase |
| Family | IPR018090 | Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic |
| Homologous_superfamily | IPR035902 | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily |
| Homologous_superfamily | IPR036320 | Glycosyl transferase family 3, N-terminal domain superfamily |
| Homologous_superfamily | IPR036566 | Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Glycosyl transferase, family 3 | Glycosyl transferase family 3, N-terminal domain | Glycosyl transferase family 3, N-terminal domain superfamily | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily | Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic | Pyrimidine-nucleoside phosphorylase, conserved site | Pyrimidine nucleoside phosphorylase, C-terminal | Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily | Thymidine/pyrimidine-nucleoside phosphorylase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2L3Z2
|
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|
UniProtKB:A0A8M9PQQ2
|
455 | |||||||||
|
UniProtKB:A0A8M3B8W2
|
455 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available