Gene
cxcr2
- ID
- ZDB-GENE-100414-1
- Name
- chemokine (C-X-C motif) receptor 2
- Symbol
- cxcr2 Nomenclature History
- Previous Names
-
- CXCR1bb (1)
- si:ch73-54b5.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits granulocyte colony-stimulating factor binding activity. Involved in defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal failure; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary bladder cancer. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Deng et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| WHIM syndrome 2 | Alliance | ?WHIM syndrome 2 | 619407 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CXC chemokine receptor 1/2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:F1Q8T9
|
340 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance