Gene

cxcr2

ID
ZDB-GENE-100414-1
Name
chemokine (C-X-C motif) receptor 2
Symbol
cxcr2 Nomenclature History
Previous Names
  • CXCR1bb (1)
  • si:ch73-54b5.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits granulocyte colony-stimulating factor binding activity. Involved in defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal failure; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary bladder cancer. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Deng et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?WHIM syndrome 2 619407
Associated With cxcr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000174 CXC chemokine receptor 1/2
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Domain Details Per Protein
Protein Length CXC chemokine receptor 1/2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:F1Q8T9 340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations