Gene
zc3h4
- ID
- ZDB-GENE-100330-1
- Name
- zinc finger CCCH-type containing 4
- Symbol
- zc3h4 Nomenclature History
- Previous Names
-
- zc3h8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity and metal ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human ZC3H4 (zinc finger CCCH-type containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22642 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35886 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42545 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45538 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zc3h4 | (2) | |
| CRISPR2-zc3h4 | (2) | |
| CRISPR3-zc3h4 | (2) | |
| CRISPR4-zc3h4 | (2) | |
| CRISPR5-zc3h4 | (2) | |
| CRISPR6-zc3h4 | (2) | |
| CRISPR7-zc3h4 | (2) | |
| CRISPR8-zc3h4 | (2) | |
| CRISPR9-zc3h4 | (2) | |
| CRISPR10-zc3h4 | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000571 | Zinc finger, CCCH-type |
| Domain | IPR041367 | E3 ligase, CCCH-type zinc finger |
| Domain | IPR054361 | Zinc finger CCCH domain-containing protein 4/6/8, CCCH zinc finger |
| Family | IPR045124 | Protein suppressor of sable-like |
| Homologous_superfamily | IPR036855 | Zinc finger, CCCH-type superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ligase, CCCH-type zinc finger | Protein suppressor of sable-like | Zinc finger CCCH domain-containing protein 4/6/8, CCCH zinc finger | Zinc finger, CCCH-type | Zinc finger, CCCH-type superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7FGZ9 | InterPro | 1340 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005157605 (1) | 5274 nt | ||
| Genomic | GenBank:CR855332 (1) | 212455 nt | ||
| Polypeptide | UniProtKB:E7FGZ9 (1) | 1340 aa |
- Comparative Orthology
- Alliance
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Russell, M.W., Raeker, M.O., Geisler, S.B., Thomas, P.E., Simmons, T.A., Bernat, J.A., Thorsson, T., Innis, J.W. (2014) Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations. Human molecular genetics. 23(16):4272-84
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