Gene
nhlrc2
- ID
- ZDB-GENE-100318-2
- Name
- NHL repeat containing 2
- Symbol
- nhlrc2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Orthologous to human NHLRC2 (NHL repeat containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Uusimaa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nhlrc2 | N/A | Uusimaa et al., 2018 |
| MO2-nhlrc2 | N/A | Uusimaa et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| FINCA syndrome | 618278 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NHL2, NHL repeat domain | NHL repeat | Six-bladed beta-propeller, TolB-like | Thioredoxin domain | Thioredoxin-like fold | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3BE96 | InterPro | 719 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nhlrc2-201
(1)
|
Ensembl | 5,008 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225B10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306763 (1) | 5035 nt | ||
| Genomic | GenBank:CR932360 (1) | 164973 nt | ||
| Polypeptide | UniProtKB:A0A8M3BE96 (1) | 719 aa |
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Uusimaa, J., Kaarteenaho, R., Paakkola, T., Tuominen, H., Karjalainen, M.K., Nadaf, J., Varilo, T., Uusi-Mäkelä, M., Suo-Palosaari, M., Pietilä, I., Hiltunen, A.E., Ruddock, L., Alanen, H., Biterova, E., Miinalainen, I., Salminen, A., Soininen, R., Manninen, A., Sormunen, R., Kaakinen, M., Vuolteenaho, R., Herva, R., Vieira, P., Dunder, T., Kokkonen, H., Moilanen, J.S., Rantala, H., Nogee, L.M., Majewski, J., Rämet, M., Hallman, M., Hinttala, R. (2018) NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease. Acta Neuropathologica. 135(5):727-742
- Zhao, J., Wang, B., Yu, H., Wang, Y., Liu, X., Zhang, Q. (2018) tdrd1 is a germline-specific and sexually dimorphically expressed gene in Paralichthys olivaceus. Gene. 673:61-69
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