Gene
mmp21
- ID
- ZDB-GENE-100226-2
- Name
- matrix metallopeptidase 21
- Symbol
- mmp21 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within determination of heart left/right asymmetry; embryonic heart tube left/right pattern formation; and regulation of heart looping. Predicted to be located in extracellular matrix. Is expressed in Kupffer's vesicle. Human ortholog(s) of this gene implicated in visceral heterotaxy 7. Orthologous to human MMP21 (matrix metallopeptidase 21).
- Genome Resources
- Note
-
XM_001342685 in ZDB-PUB-110131-35
- Comparative Information
-
- All Expression Data
- 2 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visceral heterotaxy 7 | Alliance | Heterotaxy, visceral, 7, autosomal | 616749 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR002477 | Peptidoglycan binding-like |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Hemopexin-like domain superfamily | Hemopexin-like repeats | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | Peptidoglycan binding-like | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0N9E2K8
|
599 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids