Gene

usp45

ID
ZDB-GENE-100211-2
Name
ubiquitin specific peptidase 45
Symbol
usp45 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have cysteine-type peptidase activity; thiol-dependent ubiquitin-specific protease activity; and zinc ion binding activity. Involved in photoreceptor cell maintenance. Localizes to photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis. Orthologous to human USP45 (ubiquitin specific peptidase 45).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With usp45 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leber congenital amaurosis 19 Alliance ?Leber congenital amaurosis 19 618513
Associated With usp45 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain IPR001607 Zinc finger, UBP-type
Domain IPR028889 Ubiquitin specific protease domain
Family IPR050185 Ubiquitin carboxyl-terminal hydrolase
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin specific protease, conserved site Ubiquitin specific protease domain Zinc finger, RING/FYVE/PHD-type Zinc finger, UBP-type
UniProtKB:E9QG68 803
UniProtKB:A0A8M9Q1Z3 439
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA usp45-201 (1) Ensembl 3,164 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations