Gene

atp8a2

ID

ZDB-GENE-100209-2

Name

ATPase phospholipid transporting 8A2

Symbol

atp8a2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in neuron development and phospholipid translocation. Predicted to act upstream of or within phospholipid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp8a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4	Alliance	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4	615268

Associated With atp8a2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032630	P-type ATPase, C-terminal
Domain	IPR032631	P-type ATPase, N-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Family	IPR001757	P-type ATPase
Family	IPR006539	P-type ATPase, subfamily IV
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site

Domain Details Per Protein

Protein	Length	HAD-like superfamily	HAD superfamily	P-type ATPase	P-type ATPase, A domain superfamily	P-type ATPase, C-terminal	P-type ATPase, cytoplasmic domain N	P-type ATPase, haloacid dehalogenase domain	P-type ATPase, N-terminal	P-type ATPase, phosphorylation site	P-type ATPase, subfamily IV	P-type ATPase, transmembrane domain superfamily
UniProtKB:A0A8M9PE87 InterPro	1167
UniProtKB:A0A8M9Q859 InterPro	1152
UniProtKB:A0A8M9PQZ5 InterPro	1211
UniProtKB:A0A8M2B9T5 InterPro	1177
UniProtKB:A0A8M9P645 InterPro	1156
UniProtKB:A0A8M9PX52 InterPro	1189
UniProtKB:A0A8M3B6P3 InterPro	1177
UniProtKB:X1WCP3 InterPro	1211
UniProtKB:A0A8M9Q856 InterPro	1177
UniProtKB:A0A8M9PR00 InterPro	1156
UniProtKB:A0A8M9Q410 InterPro	1177
UniProtKB:A0A8M3AP86 InterPro	1152
UniProtKB:A0A8M1RFW8 InterPro	1189
UniProtKB:A0A8M2B9Q6 InterPro	1167
UniProtKB:A0A8M6YVQ8 InterPro	1179

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atp8a2-201 (1) Ensembl	Ensembl	5,152 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-202 (1) Ensembl	Ensembl	558 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-203 (1) Ensembl	Ensembl	3,636 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-204 (1) Ensembl	Ensembl	3,597 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-205 (1) Ensembl	Ensembl	3,627 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-206 (1) Ensembl	Ensembl	4,116 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-207 (1) Ensembl	Ensembl	4,366 nt	Select Tool ZFIN BLAST
mRNA	atp8a2-208 (1) Ensembl	Ensembl	4,516 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations