Gene
pi4kaa
- ID
- ZDB-GENE-100204-2
- Name
- phosphatidylinositol 4-kinase, catalytic, alpha a
- Symbol
- pi4kaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have 1-phosphatidylinositol 4-kinase activity. Involved in embryonic pectoral fin morphogenesis. Predicted to localize to cytoplasm and plasma membrane. Is expressed in brain; pectoral fin; pharyngeal arch; and somite. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ma et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 84 | Alliance | Spastic paraplegia 84, autosomal recessive | 619621 |
| Gastrointestinal defects and immunodeficiency syndrome 2 | 619708 | ||
| Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis | 616531 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR045495 | PI4-kinase, N-terminal |
| Family | IPR015433 | Phosphatidylinositol kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
| Homologous_superfamily | IPR042236 | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | PI4-kinase, N-terminal | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BJV9
|
2097 | |||||||||
|
UniProtKB:A0A8M3AWF4
|
2128 | |||||||||
|
UniProtKB:Q49GP4
|
2059 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pi4kaa-201
(1)
|
Ensembl | 6,180 nt |
Interactions and Pathways
No data available
Plasmids
No data available