Gene
cfap70
- ID
- ZDB-GENE-091204-50
- Name
- cilia and flagella associated protein 70
- Symbol
- cfap70 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be involved in cilium assembly and cilium movement. Predicted to be located in cilium. Predicted to be active in motile cilium. Human ortholog(s) of this gene implicated in spermatogenic failure 41. Orthologous to human CFAP70 (cilia and flagella associated protein 70).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Williams et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from van Dam et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 41 | Alliance | ?Spermatogenic failure 41 | 618670 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cilia- and flagella-associated protein 70 | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PXL7 | InterPro | 821 | |||
| UniProtKB:A0A8M9Q0X2 | InterPro | 1050 | |||
| UniProtKB:F1QPL6 | InterPro | 1050 | |||
| UniProtKB:A0A8M3AQA4 | InterPro | 821 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cfap70-201
(1)
|
Ensembl | 3,153 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-254E1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009299210 (1) | |||
| Genomic | GenBank:CT573469 (1) | 156477 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0X2 (1) | 1050 aa |
- Comparative Orthology
- Alliance
- van Dam, T.J.P., Kennedy, J., van der Lee, R., de Vrieze, E., Wunderlich, K.A., Rix, S., Dougherty, G.W., Lambacher, N.J., Li, C., Jensen, V.L., Leroux, M.R., Hjeij, R., Horn, N., Texier, Y., Wissinger, Y., van Reeuwijk, J., Wheway, G., Knapp, B., Scheel, J.F., Franco, B., Mans, D.A., van Wijk, E., Képès, F., Slaats, G.G., Toedt, G., Kremer, H., Omran, H., Szymanska, K., Koutroumpas, K., Ueffing, M., Nguyen, T.T., Letteboer, S.J.F., Oud, M.M., van Beersum, S.E.C., Schmidts, M., Beales, P.L., Lu, Q., Giles, R.H., Szklarczyk, R., Russell, R.B., Gibson, T.J., Johnson, C.A., Blacque, O.E., Wolfrum, U., Boldt, K., Roepman, R., Hernandez-Hernandez, V., Huynen, M.A. (2019) CiliaCarta: An integrated and validated compendium of ciliary genes. PLoS One. 14:e0216705
- Williams, L.M., Lago, B.A., McArthur, A.G., Raphenya, A.R., Pray, N., Saleem, N., Salas, S., Paulson, K., Mangar, R.S., Liu, Y., Vo, A.H., Shavit, J.A. (2016) The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development. Aquatic toxicology (Amsterdam, Netherlands). 180:141-154
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xu, Y., Cao, J., Huang, S., Feng, D., Zhang, W., Zhu, X., Yan, X. (2015) Characterization of Tetratricopeptide Repeat-Containing Proteins Critical for Cilia Formation and Function. PLoS One. 10:e0124378
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