Gene

nnt2

ID
ZDB-GENE-091204-5
Name
nicotinamide nucleotide transhydrogenase 2
Symbol
nnt2 Nomenclature History
Previous Names
  • si:ch1073-139a18.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in NADPH regeneration. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nnt2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency 614736
Associated With nnt2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR008143 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2
Domain IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
Domain IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
Domain IPR024605 NAD(P) transhydrogenase, alpha subunit, C-terminal
Domain IPR034300 NADP transhydrogenase beta-like domain
Family IPR026255 NAD(P) transhydrogenase, alpha subunit
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal NAD(P)-binding domain superfamily NAD(P) transhydrogenase, alpha subunit NAD(P) transhydrogenase, alpha subunit, C-terminal NADP transhydrogenase beta-like domain
UniProtKB:E9QEC6 53
UniProtKB:A0A2R8Q5X4 92
UniProtKB:E9QDE7 802
UniProtKB:A0A2R8Q9E6 154
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations