Gene

gabra3

ID
ZDB-GENE-091204-365
Name
gamma-aminobutyric acid type A receptor subunit alpha3
Symbol
gabra3 Nomenclature History
Previous Names
  • si:ch211-113k9.1
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable GABA-gated chloride ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Acts upstream of or within thigmotaxis. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in brain; eye; and spinal cord. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Barnaby et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gabra3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features 301091
1 - 1 of 1
Associated With gabra3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
Family IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
Family IPR006201 Neurotransmitter-gated ion-channel
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length Gamma-aminobutyric-acid A receptor, alpha subunit Neuronal acetylcholine receptor Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily
UniProtKB:A0A8M9PV35 InterPro 305
UniProtKB:A0A8M9PJD5 InterPro 306
UniProtKB:A0A2R8QC15 InterPro 265
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gabra3-201 (1) Ensembl 374 nt
mRNA gabra3-202 (1) Ensembl 834 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations