gabra3

ID

ZDB-GENE-091204-365

Name

gamma-aminobutyric acid type A receptor subunit alpha3

Symbol

gabra3 Nomenclature History

Previous Names

si:ch211-113k9.1

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GABA-gated chloride ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Acts upstream of or within thigmotaxis. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in brain; eye; and spinal cord. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Barnaby et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gabra3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features	301091

Associated With gabra3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PV35	InterPro	305
UniProtKB:A0A8M9PJD5	InterPro	306
UniProtKB:A0A2R8QC15	InterPro	265
UniProtKB:A0AC58IBM1	InterPro	488
UniProtKB:A0AC58IBN2	InterPro	475
UniProtKB:A0AC58IBN4	InterPro	476
UniProtKB:A0AC58IBP5	InterPro	487