Gene
arhgap17b
- ID
- ZDB-GENE-080220-26
- Name
- Rho GTPase activating protein 17b
- Symbol
- arhgap17b Nomenclature History
- Previous Names
-
- si:ch211-246e12.3
- zgc:172194
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of GTPase activity and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33129 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | BAR domain | Rho GTPase-activating protein 17/44/SH3BP1-like | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1R6L8 | InterPro | 536 | |||||
| UniProtKB:A0A8M3AQE8 | InterPro | 789 | |||||
| UniProtKB:A0A2R8Q971 | InterPro | 676 | |||||
| UniProtKB:A0A8M3AQS5 | InterPro | 719 | |||||
| UniProtKB:A0A8M3B0U4 | InterPro | 718 | |||||
| UniProtKB:A0A8M3AXW1 | InterPro | 790 | |||||
| UniProtKB:A0A8M3B869 | InterPro | 747 | |||||
| UniProtKB:A0AB32T8D8 | InterPro | 675 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap17b-201
(1)
|
Ensembl | 1,904 nt | ||
| mRNA |
arhgap17b-202
(1)
|
Ensembl | 2,928 nt | ||
| mRNA |
si:ch211-246e12.3-201
(1)
|
Ensembl | 1,370 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-161I8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-1F1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-246E12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172194 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001329867 (1) | 2928 nt | ||
| Genomic | GenBank:CT573440 (1) | 159035 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXW1 (1) | 790 aa |
- Hsu, A.Y., Wang, T., Syahirah, R., Liu, S., Li, K., Zhang, W., Wang, J., Cao, Z., Tian, S., Matosevic, S., Staiger, C.J., Wan, J., Deng, Q. (2022) Rora Regulates Neutrophil Migration and Activation in Zebrafish. Frontiers in immunology. 13:756034
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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