Gene

dnah5l

ID

ZDB-GENE-091204-287

Name

dynein, axonemal, heavy chain 5 like

Symbol

dnah5l Nomenclature History

Previous Names

fj04c06
si:dkeyp-87a6.1
wu:fj04c06

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Involved in determination of heart left/right asymmetry. Predicted to localize to outer dynein arm. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5) and DNAH8 (dynein axonemal heavy chain 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Yamaguchi et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnah5l Human Ortholog

No data available

Associated With dnah5l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR004273	Dynein heavy chain region D6 P-loop domain
Domain	IPR013594	Dynein heavy chain, tail
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain	IPR035706	Dynein heavy chain, ATP-binding dynein motor region
Domain	IPR041228	Dynein heavy chain, C-terminal domain
Domain	IPR041466	Dynein heavy chain, AAA 5 extension domain
Domain	IPR041589	Dynein heavy chain 3, AAA+ lid domain
Domain	IPR041658	Dynein heavy chain AAA lid domain
Family	IPR026983	Dynein heavy chain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042219	Dynein heavy chain AAA lid domain superfamily
Homologous_superfamily	IPR042222	Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily	IPR042228	Dynein heavy chain, linker, subdomain 3
Homologous_superfamily	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain
Homologous_superfamily	IPR043160	Dynein heavy chain, C-terminal domain, barrel region

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	Dynein heavy chain	Dynein heavy chain 3, AAA+ lid domain	Dynein heavy chain, AAA1 domain, small subdomain	Dynein heavy chain, AAA 5 extension domain	Dynein heavy chain AAA lid domain	Dynein heavy chain AAA lid domain superfamily	Dynein heavy chain, AAA module D4	Dynein heavy chain, ATP-binding dynein motor region	Dynein heavy chain, coiled coil stalk	Dynein heavy chain, C-terminal domain	Dynein heavy chain, C-terminal domain, barrel region	Dynein heavy chain, domain 2, N-terminal	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Dynein heavy chain, linker	Dynein heavy chain, linker, subdomain 3	Dynein heavy chain region D6 P-loop domain	Dynein heavy chain, tail	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M1RI45 InterPro	4667

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnah5l-204 (1) Ensembl	Havana	13622 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	si:dkeyp-87a6.1-002 (1) Ensembl	Havana	286 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	si:dkeyp-87a6.1-003 (1) Ensembl	Havana	592 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations