Gene

vav3a

ID

ZDB-GENE-091204-266

Name

vav 3 guanine nucleotide exchange factor a

Symbol

vav3a Nomenclature History

Previous Names

si:ch211-223f21.2
si:ch73-383g2.1

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

null

Genome Resources

Note

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa30117	Allele with one point mutation	Unknown	Splice Site	ENU
sa44165	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With vav3a Human Ortholog

No data available

Associated With vav3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 24

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch73-383g2.1-201 (1) Ensembl	Ensembl	362 nt	Select Tool ZFIN BLAST
mRNA	si:ch73-383g2.1-202 (1) Ensembl	Ensembl	958 nt	Select Tool ZFIN BLAST
mRNA	vav3a-201 (1) Ensembl	Ensembl	505 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-383G2	FP236631	ZFIN Curated Data
Contained in	BAC	CH211-223F21	CR847965	ZFIN Curated Data

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Sequences

Type	Accession #	Sequence	Length (nt/aa)	Analysis
Genomic	GenBank:CR847965		189384 nt	Select Tool MegaBLAST Ensembl

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	VAV3	1	Ensembl:ENSG00000134215 Gene:10451 HGNC:12659 OMIM:605541	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Vav3	3	Ensembl:ENSMUSG00000033721 Gene:57257 MGI:1888518	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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