ZFIN is now using GRCz12tu for Genomic Data
Gene
map3k15
- ID
- ZDB-GENE-091204-246
- Name
- mitogen-activated protein kinase kinase kinase 15
- Symbol
- map3k15 Nomenclature History
- Previous Names
-
- si:dkey-108d10.2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Is expressed in pancreatic D cell; posterior pancreatic bud; and pronephric glomerulus. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Tarifeño-Saldivia et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR025136 | MAP3K, TRAFs-binding domain |
| Domain | IPR043969 | MAP3K, PH domain |
| Domain | IPR046872 | MAP3K, deoxyribohydrolase domain |
| Domain | IPR046873 | MAP3K, HisK-N-like globin domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | MAP3K, deoxyribohydrolase domain | MAP3K, HisK-N-like globin domain | MAP3K, PH domain | MAP3K, TRAFs-binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PX79 | InterPro | 1358 | |||||||||
| UniProtKB:A0A8M9PR29 | InterPro | 1303 | |||||||||
| UniProtKB:A0A8M9Q877 | InterPro | 1335 | |||||||||
| UniProtKB:A0A8M9PEA4 | InterPro | 1361 | |||||||||
| UniProtKB:A0A8M9PEA8 | InterPro | 1008 | |||||||||
| UniProtKB:A0A8M9PXZ5 | InterPro | 1360 | |||||||||
| UniProtKB:A0A8M3B6Q7 | InterPro | 1332 | |||||||||
| UniProtKB:A0AB32TD52 | InterPro | 1357 | |||||||||
| UniProtKB:A0AB32TMB0 | InterPro | 1300 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k15-201
(1)
|
Ensembl | 6,943 nt | ||
| mRNA |
map3k15-202
(1)
|
Ensembl | 4,658 nt | ||
| mRNA |
map3k15-203
(1)
|
Ensembl | 4,047 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers