Gene
acer3
- ID
- ZDB-GENE-091204-155
- Name
- alkaline ceramidase 3
- Symbol
- acer3 Nomenclature History
- Previous Names
-
- si:ch211-30e10.5
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in phytosphingosine biosynthetic process. Predicted to act upstream of or within ceramide metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ACER3 (alkaline ceramidase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Leukodystrophy, progressive, early childhood-onset | 617762 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008901 | Alkaline ceramidase |
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Domain Details Per Protein
| Protein | Length | Alkaline ceramidase |
|---|---|---|
|
UniProtKB:A0A8M1P6A3
|
267 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-30E10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001293692 (1) | |||
| Genomic | GenBank:BX000451 (1) | 153155 nt | ||
| Polypeptide | UniProtKB:A0A8M1P6A3 (1) | 267 aa |
- Mendelson, K., Pandey, S., Hisano, Y., Carellini, F., Das, B., Hla, T., Evans, T. (2017) The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine Levels during zebrafish embryogenesis. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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