Gene

ppip5k2

ID

ZDB-GENE-091204-125

Name

diphosphoinositol pentakisphosphate kinase 2

Symbol

ppip5k2 Nomenclature History

Previous Names

im:7137778
si:dkey-117i20.1

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have diphosphoinositol-pentakisphosphate kinase activity; inositol heptakisphosphate kinase activity; and inositol hexakisphosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7137778 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppip5k2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 100	Alliance	Deafness, autosomal recessive 100	618422

Associated With ppip5k2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR033379	Histidine acid phosphatase active site
Domain	IPR040557	VIP1, N-terminal
Family	IPR000560	Histidine phosphatase superfamily, clade-2
Family	IPR037446	Histidine acid phosphatase, VIP1 family
Homologous_superfamily	IPR029033	Histidine phosphatase superfamily

Domain Details Per Protein

Protein	Length	Histidine acid phosphatase active site	Histidine acid phosphatase, VIP1 family	Histidine phosphatase superfamily	Histidine phosphatase superfamily, clade-2	VIP1, N-terminal
UniProtKB:A0A8M3AWJ0 InterPro	1184
UniProtKB:A0A8M3AWH6 InterPro	1289
UniProtKB:A0A8M2B378 InterPro	1242
UniProtKB:A0A8M9QKU2 InterPro	1266
UniProtKB:A0A8M9QGS3 InterPro	1226
UniProtKB:A0A8M3B611 InterPro	1270
UniProtKB:A0A8M3B330 InterPro	1252
UniProtKB:A0A8M2B2S9 InterPro	1303
UniProtKB:A0A8M3BCT9 InterPro	1310
UniProtKB:A0A8M1RHG9 InterPro	1282
UniProtKB:A0A8M2B3C4 InterPro	1263

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ppip5k2-205 (1) Ensembl	Ensembl	795 nt	Select Tool ZFIN BLAST
mRNA	ppip5k2-201 (1) Ensembl	Ensembl	3,912 nt	Select Tool ZFIN BLAST
mRNA	ppip5k2-206 (1) Ensembl	Ensembl	5,059 nt	Select Tool ZFIN BLAST
ncRNA	ppip5k2-002 (1) Ensembl	Ensembl	327 nt	Select Tool ZFIN BLAST
ncRNA	ppip5k2-003 (1) Ensembl	Ensembl	429 nt	Select Tool ZFIN BLAST
ncRNA	ppip5k2-005 (1) Ensembl	Ensembl	530 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations