Gene

nox5

ID

ZDB-GENE-091120-9

Name

NADPH oxidase, EF-hand calcium binding domain 5

Symbol

nox5 Nomenclature History

Previous Names

si:ch1073-365g6.1
zmp:0000000874 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and superoxide-generating NADPH oxidase activity. Involved in neutrophil migration. Predicted to localize to integral component of membrane. Is expressed in eye; forebrain; hindbrain; midbrain; and spinal cord. Orthologous to human NOX5 (NADPH oxidase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Weaver et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nox5 Human Ortholog

No data available

Associated With nox5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR013112	FAD-binding 8
Domain	IPR013121	Ferric reductase, NAD binding domain
Domain	IPR013130	Ferric reductase transmembrane component-like domain
Domain	IPR017927	FAD-binding domain, ferredoxin reductase-type
Family	IPR000778	Cytochrome b245, heavy chain
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR017938	Riboflavin synthase-like beta-barrel
Homologous_superfamily	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

Domain Details Per Protein

Protein	Length	Cytochrome b245, heavy chain	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	FAD-binding 8	FAD-binding domain, ferredoxin reductase-type	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Ferric reductase, NAD binding domain	Ferric reductase transmembrane component-like domain	Riboflavin synthase-like beta-barrel
UniProtKB:A0A8M6YWR9 InterPro	775

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nox5-201 (1) Ensembl	Havana	2161 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations