Gene
tnk2a
- ID
- ZDB-GENE-091118-85
- Name
- tyrosine kinase, non-receptor, 2a
- Symbol
- tnk2a Nomenclature History
- Previous Names
-
- acka (1)
- si:dkey-150o13.3
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including peptidyl-tyrosine autophosphorylation; regulation of cell population proliferation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human TNK2 (tyrosine kinase non receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR015116 | Cdc42 binding domain-like |
| Domain | IPR015940 | Ubiquitin-associated domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR021619 | Mig-6 domain |
| Domain | IPR030220 | Activated CDC42 kinase 1, UBA domain |
| Domain | IPR049587 | TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR009060 | UBA-like superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR037085 | Cdc42 binding domain-like superfamily |
Domain Details Per Protein
| Protein | Length | Activated CDC42 kinase 1, UBA domain | Cdc42 binding domain-like | Cdc42 binding domain-like superfamily | Mig-6 domain | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH3 domain | SH3-like domain superfamily | Sterile alpha motif domain | TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | UBA-like superfamily | Ubiquitin-associated domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PXZ8
|
1064 | |||||||||||||||||
|
UniProtKB:A0A8M9PMC0
|
1082 | |||||||||||||||||
|
UniProtKB:A0A8M3APA4
|
1082 | |||||||||||||||||
|
UniProtKB:A0A8M3AZ65
|
1075 | |||||||||||||||||
|
UniProtKB:A0A8M3AW28
|
1064 |
Interactions and Pathways
No data available
Plasmids
No data available