Gene

pou6f2

ID

ZDB-GENE-091118-71

Name

POU class 6 homeobox 2

Symbol

pou6f2 Nomenclature History

Previous Names

si:ch211-124o16.3

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits sequence-specific DNA binding activity. Involved in regeneration. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F2 (POU class 6 homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Powell et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou6f2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Wilms tumor susceptibility-5}	601583

Associated With pou6f2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeodomain	Lambda repressor-like, DNA-binding domain superfamily	POU domain	POU domain transcription factor	POU-specific domain
UniProtKB:A0A0R4J6S2 InterPro	694
UniProtKB:A0A8M9PGB2 InterPro	719

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pou6f2-201 (1) Ensembl	Ensembl	710 nt	Select Tool ZFIN BLAST
mRNA	pou6f2-203 (1) Ensembl	Ensembl	4,198 nt	Select Tool
ncRNA	pou6f2-002 (1) Ensembl	Ensembl	570 nt	Select Tool
ncRNA	pou6f2-003 (1) Ensembl	Ensembl	809 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations