Gene

itga2.2

ID
ZDB-GENE-091118-70
Name
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2
Symbol
itga2.2 Nomenclature History
Previous Names
  • CD49b (1)
  • si:dkey-27b3.9
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to be involved in cell adhesion and integrin-mediated signaling pathway. Predicted to localize to integrin complex. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); diabetes mellitus (multiple); inherited blood coagulation disease (multiple); and iron deficiency anemia. Orthologous to human ITGA2 (integrin subunit alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa8762Allele with one point mutationUnknownSplice SiteENU
sa16899Allele with one point mutationUnknownPremature StopENU
sa41597Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With itga2.2 Human Ortholog
No data available
Associated With itga2.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain IPR002035 von Willebrand factor, type A
Domain IPR013649 Integrin alpha, first immunoglubulin-like domain
Domain IPR048285 Integrin alpha, second immunoglobulin-like domain
Domain IPR048286 Integrin alpha, third immunoglobulin-like domain
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Domain Details Per Protein
Protein Length FG-GAP repeat Integrin alpha beta-propellor Integrin alpha chain Integrin alpha chain, C-terminal cytoplasmic region, conserved site Integrin alpha, first immunoglubulin-like domain Integrin alpha, N-terminal Integrin alpha, second immunoglobulin-like domain Integrin alpha, third immunoglobulin-like domain Integrin domain superfamily von Willebrand factor A-like domain superfamily von Willebrand factor, type A
UniProtKB:F1QC06 1197
UniProtKB:A0A8M9Q352 1197
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA itga2.2-201 (1) Ensembl 3,594 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-102E1ZFIN Curated Data
Contained inBACDKEY-27B3ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanITGA25
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseItga213
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations