Gene

slc22a21

ID
ZDB-GENE-091118-62
Name
solute carrier family 22 member 21
Symbol
slc22a21 Nomenclature History
Previous Names
  • C2 (1)
  • ergothioneine transporter (1)
  • ETTzf (1)
  • si:ch1073-409b12.4
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Enables amino-acid betaine transmembrane transporter activity. Acts upstream of or within amino-acid betaine transport. Predicted to be located in membrane. Is expressed in brain; eye; integument; intestine; and kidney. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A4 (solute carrier family 22 member 4) and SLC22A5 (solute carrier family 22 member 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Pfeiffer et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ipk1TgTransgenic insertionUnknownUnknownDNA
European Zebrafish Resource Center (EZRC) (order this)
1 - 1 of 1
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Sequence Targeting Reagents
No data available
Human Disease
Associated With slc22a21 Human Ortholog
No data available
Associated With slc22a21 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR005829 Sugar transporter, conserved site
Domain IPR020846 Major facilitator superfamily domain
Family IPR005828 Major facilitator, sugar transporter-like
Homologous_superfamily IPR036259 MFS transporter superfamily
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Domain Details Per Protein
Protein Additional Resources Length Major facilitator, sugar transporter-like Major facilitator superfamily domain MFS transporter superfamily Sugar transporter, conserved site
UniProtKB:A0A0E4G213 InterPro 546
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA slc22a21-201 (1)
Ensembl
Ensembl 1,045 nt
ZFIN BLAST
mRNA slc22a21-202 (1)
Ensembl
Ensembl 1,641 nt
ZFIN BLAST
mRNA slc22a21-203 (1)
Ensembl
Ensembl 6,228 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-409B12ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001308558 (1)1641 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CU469525 (1)36295 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A0E4G213 (1)546 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
MouseSlc22a2111
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
TSV
1 - 3 of 3
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