Gene
gfi1b
- ID
- ZDB-GENE-091118-129
- Name
- growth factor independent 1B transcription repressor
- Symbol
- gfi1b Nomenclature History
- Previous Names
-
- si:ch211-231o6.2
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in definitive hemopoiesis and erythrocyte differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Is expressed in ectoderm; erythroblast; hematopoietic system; otic vesicle; and posterior lateral mesoderm. Orthologous to human GFI1B (growth factor independent 1B transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 17 | Alliance | Bleeding disorder, platelet-type, 17 | 187900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GLI C2H2-type zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:E7FBX7
|
334 | |||
|
UniProtKB:J9PE59
|
334 |
Interactions and Pathways
No data available
Plasmids
No data available