Gene
tacr1b
- ID
- ZDB-GENE-091117-17
- Name
- tachykinin receptor 1b
- Symbol
- tacr1b Nomenclature History
- Previous Names
-
- tacr1 (1)
- si:ch211-161n19.3
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable substance P receptor activity. Acts upstream of or within cellular response to cocaine. Predicted to be located in membrane. Predicted to be active in plasma membrane and sperm midpiece. Is expressed in central nervous system and somite. Human ortholog(s) of this gene implicated in developmental disorder of mental health and exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from López-Bellido et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16457 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Neurokinin NK1 receptor | Neurokinin receptor |
|---|---|---|---|---|---|---|
| UniProtKB:I6UDB5 | InterPro | 412 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tacr1b-201
(1)
|
Ensembl | 1,476 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-161N19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001281799 (1) | 1239 nt | ||
| Genomic | GenBank:BX569788 (1) | 162115 nt | ||
| Polypeptide | UniProtKB:I6UDB5 (1) | 412 aa |
- Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
- López-Bellido, R., Barreto-Valer, K., and Rodriguez, R.E. (2013) Expression of tachykinin receptors in zebrafish: influence of cocaine and opioid receptors. Journal of molecular endocrinology. 50(2):115-129
- Biran, J., Palevitch, O., Ben-Dor, S., and Levavi-Sivan, B. (2012) Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction. Proceedings of the National Academy of Sciences of the United States of America. 109(26):10269-10274
- Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C.H., Liu, X., Zhang, Y., and Lin, H. (2012) The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Molecular and Cellular Endocrinology. 361(1-2):202-212
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