Gene
tnrc6bb.2
- ID
- ZDB-GENE-091117-15
- Name
- trinucleotide repeat containing adaptor 6Bb.2
- Symbol
- tnrc6bb.2 Nomenclature History
- Previous Names
-
- si:dkey-217f16.6
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19928 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Global developmental delay with speech and behavioral abnormalities | 619243 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019486 | Argonaute hook domain |
| Domain | IPR032226 | TNRC6, PABC binding domain |
| Family | IPR052068 | GW182 domain-containing protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Argonaute hook domain | GW182 domain-containing protein | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | TNRC6, PABC binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PGS9 | InterPro | 865 | |||||
| UniProtKB:A0A8M9PTX3 | InterPro | 836 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-217f16.6-201
(1)
|
Ensembl | 2,757 nt | ||
| mRNA |
si:dkey-217f16.6-202
(1)
|
Ensembl | 832 nt | ||
| mRNA |
si:dkey-217f16.6-203
(1)
|
Ensembl | 2,670 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-217F16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021474822 (1) | |||
| Genomic | GenBank:CR788320 (1) | 174497 nt | ||
| Polypeptide | UniProtKB:A0A8M9PGS9 (1) | 865 aa |
No data available