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Gene

duox

ID
ZDB-GENE-091117-14
Name
dual oxidase
Symbol
duox Nomenclature History
Previous Names
  • duox1
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; leukocyte migration; and thyroid gland development. Predicted to be located in apical plasma membrane. Predicted to be integral component of membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; endocrine system; epidermis; eye; and pleuroperitoneal region. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX1 (dual oxidase 1) and DUOX2 (dual oxidase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With duox Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thyroid dyshormonogenesis 6 Alliance Thyroid dyshormonogenesis 6 607200
Associated With duox Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR002048 EF-hand domain
Domain IPR013112 FAD-binding 8
Domain IPR013121 Ferric reductase, NAD binding domain
Domain IPR013130 Ferric reductase transmembrane component-like domain
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Domain IPR034821 Dual oxidase, peroxidase domain
Family IPR019791 Haem peroxidase, animal-type
Homologous_superfamily IPR010255 Haem peroxidase superfamily
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR037120 Haem peroxidase domain superfamily, animal type
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length Dual oxidase, peroxidase domain EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair FAD-binding 8 FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Ferric reductase, NAD binding domain Ferric reductase transmembrane component-like domain Haem peroxidase, animal-type Haem peroxidase domain superfamily, animal type Haem peroxidase superfamily Riboflavin synthase-like beta-barrel
UniProtKB:Q08JS2 1507
UniProtKB:F1QVF2 1519
UniProtKB:A0A2R8RLY1 1499
UniProtKB:A0A2R8QJC5 450
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations