Gene

duox

ID

ZDB-GENE-091117-14

Name

dual oxidase

Symbol

duox Nomenclature History

Previous Names

duox1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; leukocyte chemotaxis; and leukocyte migration involved in inflammatory response. Predicted to be located in apical plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; endocrine system; epidermis; eye; and pleuroperitoneal region. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX1 (dual oxidase 1) and DUOX2 (dual oxidase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With duox Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thyroid dyshormonogenesis 6	Alliance	Thyroid dyshormonogenesis 6	607200

Associated With duox Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital hypothyroidism	duox^{sa13017/sa13017}	standard conditions	Chopra et al., 2019
congenital hypothyroidism	duox^{sa9892/sa9892}	standard conditions	Chopra et al., 2019
hypothyroidism	duox^{zf3299/zf3299}; ulb4Tg	standard conditions	Giusti et al., 2019
hypothyroidism	duox^{zf3298/zf3298}; ulb4Tg	standard conditions	Giusti et al., 2019
hypothyroidism	duox^{zf3300/zf3300}; ulb4Tg	standard conditions	Giusti et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR013112	FAD-binding 8
Domain	IPR013121	Ferric reductase, NAD binding domain
Domain	IPR013130	Ferric reductase transmembrane component-like domain
Domain	IPR017927	FAD-binding domain, ferredoxin reductase-type
Domain	IPR034821	Dual oxidase, peroxidase domain
Family	IPR019791	Haem peroxidase, animal-type
Family	IPR050369	Respiratory burst oxidase/Ferric reductase
Homologous_superfamily	IPR010255	Haem peroxidase superfamily
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR017938	Riboflavin synthase-like beta-barrel
Homologous_superfamily	IPR037120	Haem peroxidase domain superfamily, animal type
Homologous_superfamily	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

Domain Details Per Protein

Protein	Length	Dual oxidase, peroxidase domain	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	FAD-binding 8	FAD-binding domain, ferredoxin reductase-type	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Ferric reductase, NAD binding domain	Ferric reductase transmembrane component-like domain	Haem peroxidase, animal-type	Haem peroxidase domain superfamily, animal type	Haem peroxidase superfamily	Respiratory burst oxidase/Ferric reductase	Riboflavin synthase-like beta-barrel
UniProtKB:A0A8M6YYK2 InterPro	1528
UniProtKB:A0A8M9PVM3 InterPro	1528
UniProtKB:A0A8M9P6X2 InterPro	1527

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations