Gene
kpna1
- ID
- ZDB-GENE-091116-39
- Name
- karyopherin alpha 1 (importin alpha 5)
- Symbol
- kpna1 Nomenclature History
- Previous Names
-
- si:ch211-161h7.7
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus and postsynapse to nucleus signaling pathway. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA1 (karyopherin subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13220 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13233 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24487 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24488 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37876 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002652 | Importin-alpha, importin-beta-binding domain |
| Family | IPR024931 | Importin subunit alpha |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036975 | Importin-alpha, importin-beta-binding domain superfamily |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Atypical Arm repeat | Importin-alpha, importin-beta-binding domain | Importin-alpha, importin-beta-binding domain superfamily | Importin subunit alpha |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TBY9 | InterPro | 580 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-161H7 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_696267 (1) | 3202 nt | ||
| Genomic | GenBank:CR450812 (1) | 154456 nt | ||
| Polypeptide | UniProtKB:A0A8N7TBY9 (1) | 580 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
1 - 2 of 2
Show