Gene

recql4

ID

ZDB-GENE-091112-2

Name

RecQ helicase-like 4

Symbol

recql4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; nucleic acid binding activity; and zinc ion binding activity. Human ortholog(s) of this gene implicated in Baller-Gerold syndrome; Rothmund-Thomson syndrome; and rapadilino syndrome. Orthologous to human RECQL4 (RecQ like helicase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With recql4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Baller-Gerold syndrome	Alliance	Baller-Gerold syndrome	218600
rapadilino syndrome	Alliance	RAPADILINO syndrome	266280
Rothmund-Thomson syndrome	Alliance	Rothmund-Thomson syndrome, type 2	268400

Associated With recql4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR001878	Zinc finger, CCHC-type
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Family	IPR021110	DNA replication/checkpoint protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036875	Zinc finger, CCHC-type superfamily

Domain Details Per Protein

Protein	Length	DEAD/DEAH box helicase domain	DNA replication/checkpoint protein	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	Zinc finger, CCHC-type	Zinc finger, CCHC-type superfamily
UniProtKB:E7F8R0 InterPro
UniProtKB:E7F2M7 InterPro	1459

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	recql4-201 (1) Ensembl	Ensembl		5,578 nt	Select Tool ZFIN BLAST
mRNA	recql4-202 (1) Ensembl	Ensembl		8,798 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations