myo7ab

ID

ZDB-GENE-091110-4

Name

myosin VIIAb

Symbol

myo7ab Nomenclature History

Previous Names

si:dkey-163i6.5

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament organization; actin filament-based movement; and sensory perception of sound. Predicted to be located in apical part of cell and cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and microvillus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome type 1 (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo7ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 11	Alliance	Deafness, autosomal dominant 11	601317
autosomal recessive nonsyndromic deafness 2	Alliance	Deafness, autosomal recessive 2	600060
Usher syndrome type 1	Alliance	Usher syndrome, type 1B	276900
Usher syndrome type 1B	Alliance	Usher syndrome, type 1B	276900

Associated With myo7ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000299	FERM domain
Domain	IPR000857	MyTH4 domain
Domain	IPR001452	SH3 domain
Domain	IPR001609	Myosin head, motor domain-like
Domain	IPR002404	IRS-type PTB domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR036106	Class VII myosin, motor domain
Domain	IPR041793	Myosin VII, FERM domain C-lobe, repeat 1
Domain	IPR041794	Myosin VII, FERM domain C-lobe, repeat 2
Family	IPR051567	Unconventional Myosin ATPase
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Homologous_superfamily	IPR038185	MyTH4 domain superfamily