Gene

slc4a4b

ID

ZDB-GENE-091030-1

Name

solute carrier family 4 member 4b

Symbol

slc4a4b Nomenclature History

Previous Names

nbce1 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc4a4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Proximal renal tubular acidosis-ocular anomaly syndrome	604278

Associated With slc4a4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011531	Bicarbonate transporter-like, transmembrane domain
Domain	IPR013769	Band 3 cytoplasmic domain
Family	IPR003020	Bicarbonate transporter, eukaryotic
Family	IPR003024	Sodium bicarbonate cotransporter
Homologous_superfamily	IPR016152	Phosphotransferase/anion transporter

Domain Details Per Protein

Protein	Length	Band 3 cytoplasmic domain	Bicarbonate transporter, eukaryotic	Bicarbonate transporter-like, transmembrane domain	Phosphotransferase/anion transporter	Sodium bicarbonate cotransporter
UniProtKB:A0A8M9Q313 InterPro	918
UniProtKB:A0A8N7UV75 InterPro	1073
UniProtKB:A0A8M3B4G9 InterPro	1105
UniProtKB:A0A8M3AL80 InterPro	1122
UniProtKB:F1QD14 InterPro	1090

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	slc4a4b-201 (1) Ensembl	Ensembl		3,571 nt	Select Tool ZFIN BLAST
mRNA	slc4a4b-202 (1) Ensembl	Ensembl		3,342 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations