Gene
slc4a4b
- ID
- ZDB-GENE-091030-1
- Name
- solute carrier family 4 member 4b
- Symbol
- slc4a4b Nomenclature History
- Previous Names
-
- nbce1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022085Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12345 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa29508 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37225 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Proximal renal tubular acidosis-ocular anomaly syndrome | 604278 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Family | IPR003024 | Sodium bicarbonate cotransporter |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter | Sodium bicarbonate cotransporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q313 | InterPro | 918 | |||||
| UniProtKB:A0A8N7UV75 | InterPro | 1073 | |||||
| UniProtKB:A0A8M3B4G9 | InterPro | 1105 | |||||
| UniProtKB:A0A8M3AL80 | InterPro | 1122 | |||||
| UniProtKB:F1QD14 | InterPro | 1090 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a4b-201
(1)
|
Ensembl | 3,571 nt | ||
| mRNA |
slc4a4b-202
(1)
|
Ensembl | 3,342 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-209E20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-93M18 | ||
| Contained in | Fosmid | CH1073-376D12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009295136 (1) | 6730 nt | ||
| Genomic | GenBank:BX530036 (1) | 211643 nt | ||
| Polypeptide | UniProtKB:A0A8M3AL80 (1) | 1122 aa |
- Tong, S.K., Lee, H.L., Lee, Y.C., Wu, L.C., Tsou, Y.L., Lu, S.W., Shih, S.W., Hwang, P.P., Chou, M.Y. (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. International Journal of Molecular Sciences. 21(11)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Wang, Y.F., Lafont, A.G., Lee, Y.C., Hwang, P.P. (2016) A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Proceedings. Biological sciences. 283(1832)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lee, Y.C., Yan, J.J., Cruz, S., Horng, J.L., and Hwang, P.P. (2011) Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 300(2):C295-C307
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Yan, J.J., Chou, M.Y., Kaneko, T., and Hwang, P.P. (2007) Gene expression of Na+/H+ exchanger in zebrafish H+-ATPase-rich cells during acclimation to low-Na+ and acidic environments. American journal of physiology. Cell physiology. 293(6):C184-C1823
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