Gene
arap3
- ID
- ZDB-GENE-091019-1
- Name
- ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
- Symbol
- arap3 Nomenclature History
- Previous Names
-
- arfgap1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity; metal ion binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in lymphangiogenesis. Is expressed in cardiovascular system; neurons; and somite. Orthologous to human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Kartopawiro et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000159 | Ras-associating domain |
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001164 | Arf GTPase activating protein |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR037858 | ARAP, RhoGAP domain |
| Family | IPR052227 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR037278 | ARFGAP/RecO-like zinc finger |
| Homologous_superfamily | IPR038508 | ArfGAP domain superfamily |
Domain Details Per Protein
| Protein | Length | ARAP, RhoGAP domain | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein | Arf GTPase activating protein | PH-like domain superfamily | Pleckstrin homology domain | Ras-associating domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BKH8
|
1663 | |||||||||||||
|
UniProtKB:A0A140LH27
|
1664 |
Interactions and Pathways
No data available
Plasmids
No data available