Gene
amotl1
- ID
- ZDB-GENE-091014-3
- Name
- angiomotin like 1
- Symbol
- amotl1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel development and cell-cell adhesion. Predicted to be located in anchoring junction. Predicted to be active in bicellular tight junction; cytoplasmic vesicle; and plasma membrane. Orthologous to human AMOTL1 (angiomotin like 1).
- Genome Resources
-
- Alliance (1)
- Gene:101884950 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zheng et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Craniofaciocardiohepatic syndrome | 621192 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Angiomotin | Angiomotin, C-terminal | Angiomotin-like |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3APH7 | InterPro | 985 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009291420 (1) | 3855 nt | ||
| Genomic | GenBank:CABZ01086041 (1) | 28793 nt | ||
| Polypeptide | UniProtKB:A0A8M3APH7 (1) | 985 aa |
- Comparative Orthology
- Alliance
- Bond, S.R., Wang, N., Leybaert, L., and Naus, C.C. (2012) Pannexin 1 Ohnologs in the Teleost Lineage. The Journal of membrane biology. 245(8):483-493
- Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., and Meng, A. (2012) Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish embryoys. The Journal of biological chemistry. 287(16):13005-13015
- Zheng, Y., Vertuani, S., Nyström, S., Audebert, S., Meijer, I., Tegnebratt, T., Borg, J.P., Uhlén, P., Majumdar, A., and Holmgren, L. (2009) Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis. Circulation research. 105(3):260-270
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