ZFIN is now using GRCz12tu for Genomic Data
Gene
fancm
- ID
- ZDB-GENE-090929-1
- Name
- FA complementation group M
- Symbol
- fancm Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 3'-5' DNA helicase activity; four-way junction DNA binding activity; and four-way junction helicase activity. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and interstrand cross-link repair. Predicted to be located in nucleus. Is expressed in central nervous system; eye; and lens. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Orthologous to human FANCM (FA complementation group M).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 15 | Alliance | Premature ovarian failure 15 | 618096 |
| spermatogenic failure 28 | Alliance | Spermatogenic failure 28 | 618086 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR006166 | ERCC4 domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR031879 | Fanconi anemia group M protein, MHF binding domain |
| Domain | IPR039686 | FANCM/Mph1-like, insert domain |
| Domain | IPR044749 | FANCM, DEAH-box helicase domain |
| Domain | IPR047418 | Fanconi anemia group M protein, XPF-like nuclease domain |
| Homologous_superfamily | IPR010994 | RuvA domain 2-like |
| Homologous_superfamily | IPR011335 | Restriction endonuclease type II-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | ERCC4 domain | FANCM, DEAH-box helicase domain | FANCM/Mph1-like, insert domain | Fanconi anemia group M protein, MHF binding domain | Fanconi anemia group M protein, XPF-like nuclease domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Restriction endonuclease type II-like | RuvA domain 2-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8QLH8 | InterPro | 1761 | ||||||||||
| UniProtKB:A0AC58HLP0 | InterPro | 1830 | ||||||||||
| UniProtKB:A0AC58HLP4 | InterPro | 1817 | ||||||||||
| UniProtKB:A0AC58HLP5 | InterPro | 1817 | ||||||||||
| UniProtKB:A0AC58HLP9 | InterPro | 1818 | ||||||||||
| UniProtKB:A0AC58HLQ3 | InterPro | 1829 | ||||||||||
| UniProtKB:A0AC58HLQ4 | InterPro | 1829 | ||||||||||
| UniProtKB:A0AC58HLQ8 | InterPro | 1797 | ||||||||||
| UniProtKB:A0AC58HLQ9 | InterPro | 1798 | ||||||||||
| UniProtKB:A0AC58HLR0 | InterPro | 1797 | ||||||||||
| UniProtKB:A0AC58HLR1 | InterPro | 1797 | ||||||||||
| UniProtKB:A0AC58HLR2 | InterPro | 1818 | ||||||||||
| UniProtKB:A0AC58HLR7 | InterPro | 1795 | ||||||||||
| UniProtKB:A0AC58HLS0 | InterPro | 1795 | ||||||||||
| UniProtKB:A0AC58HLS2 | InterPro | 1807 | ||||||||||
| UniProtKB:A0AC58HLS4 | InterPro | 1817 | ||||||||||
| UniProtKB:A0AC58HLS6 | InterPro | 1817 | ||||||||||
| UniProtKB:A0AC58HLS8 | InterPro | 1816 | ||||||||||
| UniProtKB:A0AC58HLU3 | InterPro | 1798 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers