Gene
grm1b
- ID
- ZDB-GENE-090821-3
- Name
- glutamate receptor, metabotropic 1b
- Symbol
- grm1b Nomenclature History
- Previous Names
-
- grm1a
- si:ch211-278p9.5
- zmp:0000000607
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16519 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22996 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa36312 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45592 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 13 | Alliance | Spinocerebellar ataxia, autosomal recessive 13 | 614831 |
| spinocerebellar ataxia 44 | Alliance | Spinocerebellar ataxia 44 | 617691 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017979 | GPCR, family 3, conserved site |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR011500 | GPCR, family 3, nine cysteines domain |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Domain | IPR019588 | Metabotropic glutamate receptor, Homer-binding domain |
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Domain Details Per Protein
| Protein | Length | GPCR, family 3 | GPCR, family 3, conserved site | GPCR family 3, C-terminal | GPCR, family 3, metabotropic glutamate receptor | GPCR, family 3, metabotropic glutamate receptor 1 | GPCR, family 3, nine cysteines domain | GPCR, family 3, nine cysteines domain superfamily | Metabotropic Glutamate Receptor | Metabotropic glutamate receptor, Homer-binding domain | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:U3N6H4
|
1158 | |||||||||||
|
UniProtKB:A0A0R4IU63
|
1158 | |||||||||||
|
UniProtKB:A0A8M3AJM0
|
922 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278P9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001302252 (1) | |||
| Genomic | GenBank:BX005013 (1) | 164864 nt | ||
| Polypeptide | UniProtKB:A0A0R4IU63 (1) | 1158 aa |
- Varela, T., Varela, D., Martins, G., Conceição, N., Cancela, M.L. (2022) Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 12:9325
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Naderi, M., Salahinejad, A., Attaran, A., Chivers, D.P., Niyogi, S. (2020) Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Environmental pollution (Barking, Essex : 1987). 261:114060
- Naderi, M., Salahinejad, A., Attaran, A., Niyogi, S., Chivers, D.P. (2020) Rapid effects of estradiol and its receptors on object recognition and object placement in adult male zebrafish. Behavioural brain research. 384:112514
- Han, Y., Zheng, Y., Zhang, J., Hu, C. (2018) Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish. Frontiers in pharmacology. 9:160
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Haug, M.F., Gesemann, M., Mueller, T., and Neuhauss, S.C. (2013) Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). The Journal of comparative neurology. 521(7):1533-1560
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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