Gene

plekhg2

ID

ZDB-GENE-090819-1

Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 2

Symbol

plekhg2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wei et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plekhg2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Leukodystrophy and acquired microcephaly with or without dystonia	616763

Associated With plekhg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR043324	PKHG1/2/3, pleckstrin homology (PH) domain
Domain	IPR055251	SOS1/NGEF-like, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Dbl homology (DH) domain superfamily	Dbl homology domain	PH-like domain superfamily	PKHG1/2/3, pleckstrin homology (PH) domain	Pleckstrin homology domain	SOS1/NGEF-like, PH domain
UniProtKB:A0AB32T931	InterPro	553
UniProtKB:A0AB32THR0	InterPro	553

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	plekhg2-201 (1) Ensembl	Ensembl		7,811 nt	Select Tool ZFIN BLAST
mRNA	plekhg2-202 (1) Ensembl	Ensembl		6,979 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations