Gene
mespab
- ID
- ZDB-GENE-090817-2
- Name
- mesoderm posterior ab
- Symbol
- mespab Nomenclature History
- Previous Names
-
- mesp2
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within determination of heart left/right asymmetry; somite rostral/caudal axis specification; and somite specification. Predicted to be active in nucleus. Is expressed in margin; mesoderm; post-vent region; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 2. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Deshwar et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mespab | N/A | Deshwar et al., 2016 |
| TALEN1-mespab | Yabe et al., 2016 | |
| TALEN2-mespab | Yabe et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 2 | Alliance | Spondylocostal dysostosis 2, autosomal recessive | 608681 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Mesogenin/MesP | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:I2AVV9 | InterPro | 240 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mespab-201
(1)
|
Ensembl | 923 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52P2 | ||
| Contained in | BAC | DKEY-167J6 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001265583 (1) | 955 nt | ||
| Genomic | GenBank:BX572619 | 171026 nt | ||
| Polypeptide | UniProtKB:I2AVV9 (1) | 240 aa |
- Liu, Y., Du, N., Qian, B., Zou, C., Yu, Z., Xu, F., Wang, L., Qin, S., You, F., Tan, X. (2023) Characteristics of Shisa Family Genes in Zebrafish. International Journal of Molecular Sciences. 24(18):
- Keskin, S., Simsek, M.F., Vu, H.T., Yang, C., Devoto, S.H., Ay, A., Özbudak, E.M. (2019) Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish. iScience. 12:247-259
- Deshwar, A.R., Chng, S.C., Ho, L., Reversade, B., Scott, I.C. (2016) The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development. eLIFE. 5
- Deshwar, A.R., Onderisin, J.C., Aleksandrova, A., Yuan, X., Burrows, J.T., Scott, I.C. (2016) Mespaa can potently induce cardiac fates in zebrafish. Developmental Biology. 418(1):17-27
- Payumo, A.Y., McQuade, L.E., Walker, W.J., Yamazoe, S., Chen, J.K. (2016) Tbx16 regulates hox gene activation in mesodermal progenitor cells. Nature Chemical Biology. 12(9):694-701
- Yabe, T., Hoshijima, K., Yamamoto, T., Takada, S. (2016) Mesp quadruple zebrafish mutant reveals different roles of mesp genes in somite segmentation between mouse and zebrafish. Development (Cambridge, England). 143(15):2842-52
- Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
- Wanglar, C., Takahashi, J., Yabe, T., Takada, S. (2014) Tbx Protein Level Critical for Clock-Mediated Somite Positioning Is Regulated through Interaction between Tbx and Ripply. PLoS One. 9:e107928
- Cutty, S.J., Fior, R., Henriques, P.M., Saude, L., and Wardle, F.C. (2012) Identification and expression analysis of two novel members of the Mesp family in zebrafish. The International journal of developmental biology. 56(4):285-294
- Lou, X., Deshwar, A.R., Crump, J.G., and Scott, I.C. (2011) Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development (Cambridge, England). 138(15):3113-23
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